New Positive Ca(2+)-Activated K(+) Channel Gating Modulators with Selectivity for K(Ca)3.1

Small-conductance (K(Ca)2) and intermediate-conductance (K(Ca)3.1) calcium-activated K(+) channels are voltage-independent and share a common calcium/calmodulin-mediated gating mechanism. Existing positive gating modulators like EBIO, NS309, or SKA-31 activate both K(Ca)2 and K(Ca)3.1 channels with...

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Main Authors: Coleman, Nichole, Brown, Brandon M., Oliván-Viguera, Aida, Singh, Vikrant, Olmstead, Marilyn M., Valero, Marta Sofia, Köhler, Ralf, Wulff, Heike
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152908/
https://ncbi.nlm.nih.gov/pubmed/24958817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.093286
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