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New Positive Ca(2+)-Activated K(+) Channel Gating Modulators with Selectivity for K(Ca)3.1
Small-conductance (K(Ca)2) and intermediate-conductance (K(Ca)3.1) calcium-activated K(+) channels are voltage-independent and share a common calcium/calmodulin-mediated gating mechanism. Existing positive gating modulators like EBIO, NS309, or SKA-31 activate both K(Ca)2 and K(Ca)3.1 channels with...
Gorde:
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4152908/ https://ncbi.nlm.nih.gov/pubmed/24958817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.093286 |
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