A Novel Pan-Negative-Gating Modulator of K(Ca)2/3 Channels, Fluoro-Di-Benzoate, RA-2, Inhibits Endothelium-Derived Hyperpolarization–Type Relaxation in Coronary Artery and Produces Bradycardia In Vivo

Small/intermediate conductance K(Ca) channels (K(Ca)2/3) are Ca(2+)/calmodulin regulated K(+) channels that produce membrane hyperpolarization and shape neurologic, epithelial, cardiovascular, and immunologic functions. Moreover, they emerged as therapeutic targets to treat cardiovascular disease, c...

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Bibliografiske detaljer
Udgivet i:Mol Pharmacol
Main Authors: Oliván-Viguera, Aida, Valero, Marta Sofía, Coleman, Nicole, Brown, Brandon M., Laría, Celia, Divina Murillo, María, Gálvez, José A., Díaz-de-Villegas, María D., Wulff, Heike, Badorrey, Ramón, Köhler, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293453/
https://ncbi.nlm.nih.gov/pubmed/25468883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095745
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