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Role of Multidrug Resistance–Associated Protein 4 in the Basolateral Efflux of Hepatically Derived Enalaprilat

Hepatic uptake and efflux transporters govern the systemic and hepatic exposure of many drugs and metabolites. Enalapril is a pharmacologically inactive prodrug of enalaprilat. Following oral administration, enalapril is converted to enalaprilat in hepatocytes and undergoes translocation into the sy...

詳細記述

保存先:
書誌詳細
主要な著者: Ferslew, Brian C., Köck, Kathleen, Bridges, Arlene S., Brouwer, Kim L. R.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152871/
https://ncbi.nlm.nih.gov/pubmed/24958844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.057554
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