Risk Factors for Development of Cholestatic Drug-Induced Liver Injury: Inhibition of Hepatic Basolateral Bile Acid Transporters Multidrug Resistance-Associated Proteins 3 and 4

Impaired hepatic bile acid export may contribute to development of cholestatic drug-induced liver injury (DILI). The multidrug resistance-associated proteins (MRP) 3 and 4 are postulated to be compensatory hepatic basolateral bile acid efflux transporters when biliary excretion by the bile salt expo...

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Detalhes bibliográficos
Main Authors: Köck, Kathleen, Ferslew, Brian C., Netterberg, Ida, Yang, Kyunghee, Urban, Thomas J., Swaan, Peter W., Stewart, Paul W., Brouwer, Kim L. R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Special Section on Transporters in Toxicity and Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965904/
https://ncbi.nlm.nih.gov/pubmed/24154606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.054304
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