Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition II: Characterization of Hepatic Elimination by Basolateral, Biliary, and Metabolic Clearance Pathways in Rat Isolated Perfused Liver

Basolateral efflux clearance (CL(BL)) contributes significantly to rosuvastatin (RSV) elimination in sandwich-cultured hepatocytes (SCH). The contribution of CL(BL) to RSV hepatic elimination was determined in single-pass isolated perfused livers (IPLs) from wild-type (WT) and multidrug resistance–a...

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Detalhes bibliográficos
Main Authors: Pfeifer, Nathan D., Bridges, Arlene S., Ferslew, Brian C., Hardwick, Rhiannon N., Brouwer, Kim L. R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836312/
https://ncbi.nlm.nih.gov/pubmed/24080682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.208314
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