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Role of Multidrug Resistance–Associated Protein 4 in the Basolateral Efflux of Hepatically Derived Enalaprilat

Hepatic uptake and efflux transporters govern the systemic and hepatic exposure of many drugs and metabolites. Enalapril is a pharmacologically inactive prodrug of enalaprilat. Following oral administration, enalapril is converted to enalaprilat in hepatocytes and undergoes translocation into the sy...

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Hlavní autoři: Ferslew, Brian C., Köck, Kathleen, Bridges, Arlene S., Brouwer, Kim L. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152871/
https://ncbi.nlm.nih.gov/pubmed/24958844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.057554
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