Real-time detection of DNA hybridization and melting on oligonucleotide arrays by using optical wave guides.

The challenge of the Human Genome Project is to increase the rate of DNA sequence acquisition by two orders of magnitude to complete sequencing of the human genome by the year 2000. The present work describes a rapid detection method using a two-dimensional optical wave guide that allows measurement...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Stimpson, D I, Hoijer, J V, Hsieh, W T, Jou, C, Gordon, J, Theriault, T, Gamble, R, Baldeschwieler, J D
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7603999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.14.6379
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