Real-time detection of DNA hybridization and melting on oligonucleotide arrays by using optical wave guides.

The challenge of the Human Genome Project is to increase the rate of DNA sequence acquisition by two orders of magnitude to complete sequencing of the human genome by the year 2000. The present work describes a rapid detection method using a two-dimensional optical wave guide that allows measurement...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Stimpson, D I, Hoijer, J V, Hsieh, W T, Jou, C, Gordon, J, Theriault, T, Gamble, R, Baldeschwieler, J D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7603999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.14.6379
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