Real-time detection of DNA hybridization and melting on oligonucleotide arrays by using optical wave guides.

The challenge of the Human Genome Project is to increase the rate of DNA sequence acquisition by two orders of magnitude to complete sequencing of the human genome by the year 2000. The present work describes a rapid detection method using a two-dimensional optical wave guide that allows measurement...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Stimpson, D I, Hoijer, J V, Hsieh, W T, Jou, C, Gordon, J, Theriault, T, Gamble, R, Baldeschwieler, J D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7603999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.14.6379
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