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Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics

Cardiac titin is the main determinant of sarcomere stiffness during diastolic relaxation. To explore whether titin stiffness affects the kinetics of cardiac myofibrillar contraction and relaxation, we used subcellular myofibrils from the left ventricles of homozygous and heterozygous N2B-knockout mi...

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Bibliografski detalji
Glavni autori: Elhamine, Fatiha, Radke, Michael H., Pfitzer, Gabriele, Granzier, Henk, Gotthardt, Michael, Stehle, Robert
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150059/
https://ncbi.nlm.nih.gov/pubmed/24982444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.141796
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