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Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics

Cardiac titin is the main determinant of sarcomere stiffness during diastolic relaxation. To explore whether titin stiffness affects the kinetics of cardiac myofibrillar contraction and relaxation, we used subcellular myofibrils from the left ventricles of homozygous and heterozygous N2B-knockout mi...

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Autores principales: Elhamine, Fatiha, Radke, Michael H., Pfitzer, Gabriele, Granzier, Henk, Gotthardt, Michael, Stehle, Robert
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150059/
https://ncbi.nlm.nih.gov/pubmed/24982444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.141796
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