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Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics
Cardiac titin is the main determinant of sarcomere stiffness during diastolic relaxation. To explore whether titin stiffness affects the kinetics of cardiac myofibrillar contraction and relaxation, we used subcellular myofibrils from the left ventricles of homozygous and heterozygous N2B-knockout mi...
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Autores principales: | , , , , , |
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Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
The Company of Biologists
2014
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Materias: | |
Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4150059/ https://ncbi.nlm.nih.gov/pubmed/24982444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.141796 |
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