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Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region deficient mice

Previous work suggests that titin-based passive tension is a factor in the Frank-Starling mechanism of the heart, by increasing length-dependent activation (LDA) through an increase in calcium sensitivity at long sarcomere length. We tested this hypothesis in a mouse model (N2B KO model) in which ti...

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Detalhes bibliográficos
Main Authors: Lee, Eun-Jeong, Peng, Jun, Radke, Michael, Gotthardt, Michael, Granzier, Henk L
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917497/
https://ncbi.nlm.nih.gov/pubmed/20507834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.05.006
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