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Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region deficient mice
Previous work suggests that titin-based passive tension is a factor in the Frank-Starling mechanism of the heart, by increasing length-dependent activation (LDA) through an increase in calcium sensitivity at long sarcomere length. We tested this hypothesis in a mouse model (N2B KO model) in which ti...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2917497/ https://ncbi.nlm.nih.gov/pubmed/20507834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.05.006 |
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