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Mechanics on Myocardium Deficient in the N2B Region of Titin: The Cardiac-Unique Spring Element Improves Efficiency of the Cardiac Cycle

Titin (also known as connectin) is an intrasarcomeric muscle protein that functions as a molecular spring and generates passive tension upon muscle stretch. The N2B element is a cardiac-specific spring element within titin's extensible region. Our goal was to study the contribution of the N2B e...

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Detalhes bibliográficos
Main Authors: Nedrud, Joshua, Labeit, Siegfried, Gotthardt, Michael, Granzier, Henk
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177072/
https://ncbi.nlm.nih.gov/pubmed/21943419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.06.054
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