Modulation of Titin-Based Stiffness by Disulfide Bonding in the Cardiac Titin N2-B Unique Sequence

The giant protein titin is responsible for the elasticity of nonactivated muscle sarcomeres. Titin-based passive stiffness in myocardium is modulated by titin-isoform switching and protein-kinase (PK)A- or PKG-dependent titin phosphorylation. Additional modulatory effects on titin stiffness may aris...

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Detalhes bibliográficos
Main Authors: Grützner, Anika, Garcia-Manyes, Sergi, Kötter, Sebastian, Badilla, Carmen L., Fernandez, Julio M., Linke, Wolfgang A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Muscle, Motility, and Motor Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718153/
https://ncbi.nlm.nih.gov/pubmed/19651040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.05.037
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