Detection of “oncometabolite” 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma

Somatic mutations in isocitrate dehydrogenase (IDH)1 and 2 have been identified in a subset of gliomas, rendering these tumors with elevated levels of “oncometabolite,” D-2-hydroxyglutarate (2HG). Herein, we report that 2HG can be precisely detected by magnetic resonance (MR) in human glioma specime...

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Bibliografiske detaljer
Main Authors: Kalinina, Juliya, Carroll, Anne, Wang, Liya, Yu, Qiqi, Mancheno, Danny E., Wu, Shaoxiong, Liu, Frank, Ahn, Jun, He, Miao, Mao, Hui, Van Meir, Erwin G.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147374/
https://ncbi.nlm.nih.gov/pubmed/22426639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-012-0888-x
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