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Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase

PURPOSE: Elevation in D-2-Hydroxyglutarate (D-2HG) has recently emerged as a mandatory byproduct of mutated Isocitrate Dehydrogenase (IDH) genes 1 and 2 in glioma patients. The goal of the present study was to demonstrate the feasibility of detection of elevated levels of D-2HG in the cerebrospinal...

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書誌詳細
出版年:Clin Cancer Res
主要な著者: Kalinina, Juliya, Ahn, Jun, Devi, Narra S., Wang, Liya, Li, Yuancheng, Olson, Jeffrey J., Glantz, Michael, Smith, Thomas, Kim, Ella L., Giese, Alf, Jensen, Randy L., Chen, Clark C., Carter, Bob S., Mao, Hui, He, Miao, Van Meir, Erwin G.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443654/
https://ncbi.nlm.nih.gov/pubmed/27340277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2965
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