Diagnostic Value of Plasma and Urinary 2-Hydroxyglutarate to Identify Patients With Isocitrate Dehydrogenase-Mutated Glioma

BACKGROUND. Mutant isocitrate dehydrogenase (IDH) 1/2 enzymes can convert α-ketoglutarate into 2-hydroxyglutarate (2HG). The aim of the present study was to explore whether 2HG in plasma and urine could predict the presence of IDH1/2 mutations in patients with glioma. MATERIALS AND METHODS. All pati...

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Detalhes bibliográficos
Publicado no:Oncologist
Main Authors: Lombardi, Giuseppe, Corona, Giuseppe, Bellu, Luisa, Puppa, Alessandro Della, Pambuku, Ardi, Fiduccia, Pasquale, Bertorelle, Roberta, Gardiman, Marina Paola, D’Avella, Domenico, Toffoli, Giuseppe, Zagonel, Vittorina
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2015
Assuntos:
Neuro-Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425377/
https://ncbi.nlm.nih.gov/pubmed/25862748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2014-0266
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