Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase

PURPOSE: Elevation in D-2-Hydroxyglutarate (D-2HG) has recently emerged as a mandatory byproduct of mutated Isocitrate Dehydrogenase (IDH) genes 1 and 2 in glioma patients. The goal of the present study was to demonstrate the feasibility of detection of elevated levels of D-2HG in the cerebrospinal...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Kalinina, Juliya, Ahn, Jun, Devi, Narra S., Wang, Liya, Li, Yuancheng, Olson, Jeffrey J., Glantz, Michael, Smith, Thomas, Kim, Ella L., Giese, Alf, Jensen, Randy L., Chen, Clark C., Carter, Bob S., Mao, Hui, He, Miao, Van Meir, Erwin G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443654/
https://ncbi.nlm.nih.gov/pubmed/27340277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2965
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