Magnetic Resonance of 2-Hydroxyglutarate in IDH1-Mutated Low-Grade Gliomas

Recent studies have indicated that a significant survival advantage is conferred to patients with gliomas whose lesions harbor mutations in the genes isocitrate dehydrogenase 1 and 2 (IDH1/2). IDH1/2 mutations result in aberrant enzymatic production of the potential oncometabolite D-2-hydroxyglutara...

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Main Authors: Elkhaled, Adam, Jalbert, Llewellyn E., Phillips, Joanna J., Yoshihara, Hikari A. I., Parvataneni, Rupa, Srinivasan, Radhika, Bourne, Gabriela, Berger, Mitchel S., Chang, Susan M., Cha, Soonmee, Nelson, Sarah J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772177/
https://ncbi.nlm.nih.gov/pubmed/22238333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002796
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