Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations

Lysosomes contribute to a multitude of cellular processes, and the pH of the lysosomal lumen plays a central mechanistic role in many of these functions. In addition to controlling the rate of enzymatic degradation for material delivered through autophagic or phagocytotic pathways, lysosomal pH regu...

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Main Authors: Guha, Sonia, Coffey, Erin E., Lu, Wennan, Lim, Jason C., Beckel, Jonathan M., Laties, Alan M., Boesze-Battaglia, Kathleen, Mitchell, Claire H.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143779/
https://ncbi.nlm.nih.gov/pubmed/25152362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2014.05.013
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