Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells

Lysosomal enzymes function optimally in acidic environments, and elevation of lysosomal pH can impede their ability to degrade material delivered to lysosomes through autophagy or phagocytosis. We hypothesize that abnormal lysosomal pH is a key aspect in diseases of accumulation and that restoring l...

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Detalhes bibliográficos
Main Authors: Baltazar, Gabriel C., Guha, Sonia, Lu, Wennan, Lim, Jason, Boesze-Battaglia, Kathleen, Laties, Alan M., Tyagi, Puneet, Kompella, Uday B., Mitchell, Claire H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525582/
https://ncbi.nlm.nih.gov/pubmed/23272048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049635
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