Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells

Lysosomal enzymes function optimally in acidic environments, and elevation of lysosomal pH can impede their ability to degrade material delivered to lysosomes through autophagy or phagocytosis. We hypothesize that abnormal lysosomal pH is a key aspect in diseases of accumulation and that restoring l...

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Главные авторы: Baltazar, Gabriel C., Guha, Sonia, Lu, Wennan, Lim, Jason, Boesze-Battaglia, Kathleen, Laties, Alan M., Tyagi, Puneet, Kompella, Uday B., Mitchell, Claire H.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525582/
https://ncbi.nlm.nih.gov/pubmed/23272048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049635
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