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Restoration of Lysosomal pH in RPE Cells from Cultured Human and ABCA4(−/−) Mice: Pharmacologic Approaches and Functional Recovery
PURPOSE: Degradation of engulfed material is primarily mediated by lysosomal enzymes that function optimally within a narrow range of acidic pH values. RPE cells are responsible for daily degradation of photoreceptor outer segments and are thus particularly susceptible to perturbations in lysosomal...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2279299/ https://ncbi.nlm.nih.gov/pubmed/18235027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-0675 |
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