Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells

The role of the cystic fibrosis transmembrane conductance regulator (CFTR) in lysosomal acidification has been difficult to determine. We demonstrate here that CFTR contributes more to the reacidification of lysosomes from an elevated pH than to baseline pH maintenance. Lysosomal alkalinization is i...

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Autors principals: Liu, Ji, Lu, Wennan, Guha, Sonia, Baltazar, Gabriel C., Coffey, Erin E., Laties, Alan M., Rubenstein, Ronald C., Reenstra, William W., Mitchell, Claire H.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404519/
https://ncbi.nlm.nih.gov/pubmed/22572847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00278.2011
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