Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor

Lysosomal enzymes function optimally at low pH; as accumulation of waste material contributes to cell aging and disease, dysregulation of lysosomal pH may represent an early step in several pathologies. Here, we demonstrate that stimulation of the P2X7 receptor (P2X7R) for ATP alkalinizes lysosomes...

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Detalhes bibliográficos
Main Authors: Guha, Sonia, Baltazar, Gabriel C., Coffey, Erin E., Tu, Leigh-Anne, Lim, Jason C., Beckel, Jonathan M., Patel, Shaun, Eysteinsson, Thor, Lu, Wennan, O'Brien-Jenkins, Ann, Laties, Alan M., Mitchell, Claire H.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804754/
https://ncbi.nlm.nih.gov/pubmed/23964074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-236166
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