Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor

Lysosomal enzymes function optimally at low pH; as accumulation of waste material contributes to cell aging and disease, dysregulation of lysosomal pH may represent an early step in several pathologies. Here, we demonstrate that stimulation of the P2X7 receptor (P2X7R) for ATP alkalinizes lysosomes...

詳細記述

保存先:
書誌詳細
主要な著者: Guha, Sonia, Baltazar, Gabriel C., Coffey, Erin E., Tu, Leigh-Anne, Lim, Jason C., Beckel, Jonathan M., Patel, Shaun, Eysteinsson, Thor, Lu, Wennan, O'Brien-Jenkins, Ann, Laties, Alan M., Mitchell, Claire H.
フォーマット: Artigo
言語:Inglês
出版事項: Federation of American Societies for Experimental Biology 2013
主題:
Research Communications
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804754/
https://ncbi.nlm.nih.gov/pubmed/23964074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-236166
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