Poly (ADP-ribose) polymerase inhibitor CEP-8983 synergizes with bendamustine in chronic lymphocytic leukemia cells in vitro

DNA repair aberrations and associated chromosomal instability is a feature of chronic lymphocytic leukemia (CLL). To evaluate if DNA repair insufficiencies are related to methylation changes, we examined the methylation of nine promoter regions of DNA repair proteins by bisulfide sequencing in 26 CL...

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Autori principali: Dilley, Robert L., Poh, Weijie, Gladstone, Douglas E., Herman, James G., Showel, Margaret M., Karp, Judith E., McDevitt, Michael A., Pratz, Keith W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142574/
https://ncbi.nlm.nih.gov/pubmed/24439051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2013.12.019
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