Involvement of homologous recombination in the synergism between cisplatin and poly (ADP‐ribose) polymerase inhibition

Poly (ADP‐ribose) polymerase (PARP) plays a critical role in responding to DNA damage, by activating DNA repair pathways responsible for cellular survival. Inhibition of PARP is used to treat certain solid cancers, such as breast and ovarian cancers. However, its effectiveness with other solid cance...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Sakogawa, Kenji, Aoki, Yoshiro, Misumi, Keizo, Hamai, Yoichi, Emi, Manabu, Hihara, Jun, Shi, Lin, Kono, Kazuteru, Horikoshi, Yasunori, Sun, Jiying, Ikura, Tsuyoshi, Okada, Morihito, Tashiro, Satoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2013
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653531/
https://ncbi.nlm.nih.gov/pubmed/24033642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12281
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