Coordinated Regulation of TIP60 and Poly(ADP-Ribose) Polymerase 1 in Damaged-Chromatin Dynamics

The dynamic exchange of histones alleviates the nucleosome barrier and simultaneously facilitates various aspects of cellular DNA metabolism, such as DNA repair and transcription. In response to DNA damage, the acetylation of Lys5 in the histone variant H2AX, catalyzed by TIP60, plays a key role in...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Ikura, Masae, Furuya, Kanji, Fukuto, Atsuhiko, Matsuda, Ryo, Adachi, Jun, Matsuda, Tomonari, Kakizuka, Akira, Ikura, Tsuyoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859686/
https://ncbi.nlm.nih.gov/pubmed/26976643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01085-15
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