Coordinated Regulation of TIP60 and Poly(ADP-Ribose) Polymerase 1 in Damaged-Chromatin Dynamics

The dynamic exchange of histones alleviates the nucleosome barrier and simultaneously facilitates various aspects of cellular DNA metabolism, such as DNA repair and transcription. In response to DNA damage, the acetylation of Lys5 in the histone variant H2AX, catalyzed by TIP60, plays a key role in...

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Published in:Mol Cell Biol
Main Authors: Ikura, Masae, Furuya, Kanji, Fukuto, Atsuhiko, Matsuda, Ryo, Adachi, Jun, Matsuda, Tomonari, Kakizuka, Akira, Ikura, Tsuyoshi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859686/
https://ncbi.nlm.nih.gov/pubmed/26976643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01085-15
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