Poly(ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms

PURPOSE: DNA repair defects have been previously reported in myeloproliferative neoplasms (MPNs). Inhibitors of poly(ADP-ribose) polymerase (PARP) have shown activity in solid tumors with defects in homologous recombination (HR). The present study was performed to assess MPN sensitivity to PARP inhi...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Pratz, Keith W., Koh, Brian, Patel, Anand G., Flatten, Karen S., Poh, Weijie, Herman, James G., Dilley, Robert, Harrell, Maria I., Smith, B. Douglas, Karp, Judith E., Swisher, Elizabeth M., McDevitt, Michael A., Kaufmann, Scott H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041297/
https://ncbi.nlm.nih.gov/pubmed/26979391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2351
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