Poly(ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms

PURPOSE: DNA repair defects have been previously reported in myeloproliferative neoplasms (MPNs). Inhibitors of poly(ADP-ribose) polymerase (PARP) have shown activity in solid tumors with defects in homologous recombination (HR). The present study was performed to assess MPN sensitivity to PARP inhi...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Pratz, Keith W., Koh, Brian, Patel, Anand G., Flatten, Karen S., Poh, Weijie, Herman, James G., Dilley, Robert, Harrell, Maria I., Smith, B. Douglas, Karp, Judith E., Swisher, Elizabeth M., McDevitt, Michael A., Kaufmann, Scott H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041297/
https://ncbi.nlm.nih.gov/pubmed/26979391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2351
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