Poly(ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms

PURPOSE: DNA repair defects have been previously reported in myeloproliferative neoplasms (MPNs). Inhibitors of poly(ADP-ribose) polymerase (PARP) have shown activity in solid tumors with defects in homologous recombination (HR). The present study was performed to assess MPN sensitivity to PARP inhi...

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Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Pratz, Keith W., Koh, Brian, Patel, Anand G., Flatten, Karen S., Poh, Weijie, Herman, James G., Dilley, Robert, Harrell, Maria I., Smith, B. Douglas, Karp, Judith E., Swisher, Elizabeth M., McDevitt, Michael A., Kaufmann, Scott H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041297/
https://ncbi.nlm.nih.gov/pubmed/26979391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2351
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