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Poly (ADP-ribose) polymerase inhibitor CEP-8983 synergizes with bendamustine in chronic lymphocytic leukemia cells in vitro

DNA repair aberrations and associated chromosomal instability is a feature of chronic lymphocytic leukemia (CLL). To evaluate if DNA repair insufficiencies are related to methylation changes, we examined the methylation of nine promoter regions of DNA repair proteins by bisulfide sequencing in 26 CL...

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Detalhes bibliográficos
Main Authors: Dilley, Robert L., Poh, Weijie, Gladstone, Douglas E., Herman, James G., Showel, Margaret M., Karp, Judith E., McDevitt, Michael A., Pratz, Keith W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142574/
https://ncbi.nlm.nih.gov/pubmed/24439051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2013.12.019
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