Megalin-Mediated Specific Uptake of Chitosan/siRNA Nanoparticles in Mouse Kidney Proximal Tubule Epithelial Cells Enables AQP1 Gene Silencing

RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mic...

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Bibliografische gegevens
Hoofdauteurs: Gao, Shan, Hein, San, Dagnæs-Hansen, Frederik, Weyer, Kathrin, Yang, Chuanxu, Nielsen, Rikke, Christensen, Erik I, Fenton, Robert A, Kjems, Jørgen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ivyspring International Publisher 2014
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142293/
https://ncbi.nlm.nih.gov/pubmed/25157280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.7866
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