Megalin-Mediated Specific Uptake of Chitosan/siRNA Nanoparticles in Mouse Kidney Proximal Tubule Epithelial Cells Enables AQP1 Gene Silencing

RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mic...

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Detaylı Bibliyografya
Asıl Yazarlar: Gao, Shan, Hein, San, Dagnæs-Hansen, Frederik, Weyer, Kathrin, Yang, Chuanxu, Nielsen, Rikke, Christensen, Erik I, Fenton, Robert A, Kjems, Jørgen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Ivyspring International Publisher 2014
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142293/
https://ncbi.nlm.nih.gov/pubmed/25157280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.7866
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