Megalin-Mediated Specific Uptake of Chitosan/siRNA Nanoparticles in Mouse Kidney Proximal Tubule Epithelial Cells Enables AQP1 Gene Silencing

RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gao, Shan, Hein, San, Dagnæs-Hansen, Frederik, Weyer, Kathrin, Yang, Chuanxu, Nielsen, Rikke, Christensen, Erik I, Fenton, Robert A, Kjems, Jørgen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Ivyspring International Publisher 2014
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142293/
https://ncbi.nlm.nih.gov/pubmed/25157280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.7866
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