Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases

Substrates enter the cylindrical 20S proteasome through a gated channel that is regulated by the ATPases in the 19S regulatory particle in eukaryotes or the homologous PAN ATPase complex in archaea. These ATPases contain a conserved C-terminal hydrophobic-tyrosine-X (HbYX) motif that triggers gate o...

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Hauptverfasser: Rabl, Julius, Smith, David M., Yu, Yadong, Chang, Shih-Chung, Goldberg, Alfred L., Cheng, Yifan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141531/
https://ncbi.nlm.nih.gov/pubmed/18471981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.03.004
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