Docking of the Proteasomal ATPases’ C-termini in the 20S Proteasomes alpha Ring Opens the Gate for Substrate Entry

The 20S proteasome functions in protein degradation in eukaryotes together with the 19S ATPases or in archaea with the homologous PAN ATPase complex. PAN and the 19S ATPases contain a conserved C-terminal hydrophobic-tyrosine-X motif (HbYX). We show that these residues are essential for PAN to assoc...

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Hlavní autoři: Smith, David M., Chang, Shih-Chung, Park, Soyeon, Finley, Daniel, Cheng, Yifan, Goldberg, Alfred
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2083707/
https://ncbi.nlm.nih.gov/pubmed/17803938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.06.033
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