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Docking of the Proteasomal ATPases’ C-termini in the 20S Proteasomes alpha Ring Opens the Gate for Substrate Entry
The 20S proteasome functions in protein degradation in eukaryotes together with the 19S ATPases or in archaea with the homologous PAN ATPase complex. PAN and the 19S ATPases contain a conserved C-terminal hydrophobic-tyrosine-X motif (HbYX). We show that these residues are essential for PAN to assoc...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2083707/ https://ncbi.nlm.nih.gov/pubmed/17803938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.06.033 |
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