Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism

For optimal proteolytic function, the central core of the proteasome (core particle (CP) or 20S) has to associate with activators. We investigated the impact of the yeast activator Blm10 on proteasomal peptide and protein degradation. We found enhanced degradation of peptide substrates in the presen...

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Hlavní autoři: Dange, Thomas, Smith, David, Noy, Tahel, Rommel, Philipp C., Jurzitza, Lukas, Cordero, Radames J. B., Legendre, Anne, Finley, Daniel, Goldberg, Alfred L., Schmidt, Marion
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234834/
https://ncbi.nlm.nih.gov/pubmed/22025621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300178
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