Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism

For optimal proteolytic function, the central core of the proteasome (core particle (CP) or 20S) has to associate with activators. We investigated the impact of the yeast activator Blm10 on proteasomal peptide and protein degradation. We found enhanced degradation of peptide substrates in the presen...

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Détails bibliographiques
Auteurs principaux: Dange, Thomas, Smith, David, Noy, Tahel, Rommel, Philipp C., Jurzitza, Lukas, Cordero, Radames J. B., Legendre, Anne, Finley, Daniel, Goldberg, Alfred L., Schmidt, Marion
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Protein Synthesis and Degradation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234834/
https://ncbi.nlm.nih.gov/pubmed/22025621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300178
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