Proteasomes Associated with the Blm10 Activator Protein Antagonize Mitochondrial Fission through Degradation of the Fission Protein Dnm1

The conserved Blm10/PA200 activators bind to the proteasome core particle gate and facilitate turnover of peptides and unfolded proteins in vitro. We report here that Blm10 is required for the maintenance of functional mitochondria. BLM10 expression is induced 25-fold upon a switch from fermentation...

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Detalhes bibliográficos
Main Authors: Tar, Krisztina, Dange, Thomas, Yang, Ciyu, Yao, Yanhua, Bulteau, Anne-Laure, Salcedo, Elena Fernandez, Braigen, Stephen, Bouillaud, Frederic, Finley, Daniel, Schmidt, Marion
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002118/
https://ncbi.nlm.nih.gov/pubmed/24604417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554105
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