The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin

The Blm10/PA200 family of proteasome activators modulates the peptidase activity of the core particle (20S CP). They participate in opening the 20S CP gate, thus facilitating the degradation of unstructured proteins such as tau and Dnm1 in a ubiquitin- and ATP-independent manner. Furthermore, PA200...

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Vydáno v:Biomolecules
Hlavní autoři: Aladdin, Azzam, Yao, Yanhua, Yang, Ciyu, Kahlert, Günther, Ghani, Marvi, Király, Nikolett, Boratkó, Anita, Uray, Karen, Dittmar, Gunnar, Tar, Krisztina
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699873/
https://ncbi.nlm.nih.gov/pubmed/33233776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10111581
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