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UBIQUITINATED PROTEINS ACTIVATE THE PROTEASOME BY BINDING TO USP14/UBP6 WHICH CAUSES 20S GATE OPENING
In eukaryotic cells, ubiquitination of proteins leads to their degradation by the 26S proteasome. We tested if the ubiquitin (Ub) chain also regulates the proteasome’s capacity for proteolysis. After incubation with polyubiquitinated proteins, 26S proteasomes hydrolyzed peptides and proteins 2–7 fol...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796264/ https://ncbi.nlm.nih.gov/pubmed/20005843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.11.015 |
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