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Ubiquitinated Proteins Activate the Proteasomal ATPases by Binding to Usp14 or Uch37 Homologs

Degradation of ubiquitinated proteins by 26 S proteasomes requires ATP hydrolysis, but it is unclear how the proteasomal ATPases are regulated and how proteolysis, substrate deubiquitination, degradation, and ATP hydrolysis are coordinated. Polyubiquitinated proteins were shown to stimulate ATP hydr...

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Detalhes bibliográficos
Main Authors: Peth, Andreas, Kukushkin, Nikolay, Bossé, Marc, Goldberg, Alfred L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597817/
https://ncbi.nlm.nih.gov/pubmed/23341450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441907
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