Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP)

Defects in the regulation of apoptosis are one main cause of cancer development and may result from overexpression of anti-apoptotic proteins such as the X-linked inhibitor of apoptosis protein (XIAP). XIAP is frequently overexpressed in human leukemia and prostate and breast tumors. Inhibition of a...

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Main Authors: Seiter, Maximilian A., Salcher, Stefan, Rupp, Martina, Hagenbuchner, Judith, Kiechl-Kohlendorfer, Ursula, Mortier, Jérémie, Wolber, Gerhard, Rollinger, Judith M., Obexer, Petra, Ausserlechner, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141193/
https://ncbi.nlm.nih.gov/pubmed/25161875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.07.001
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