Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å co-crystal structure of gp120 and M48U1

The interface between HIV-1 gp120 envelope glycoprotein and CD4 receptor contains an unusual interfacial cavity, the “Phe43 cavity”, which miniprotein mimetics of CD4 with non-natural extensions can potentially utilize to enhance their neutralization of HIV-1. Here we report co-crystal structures of...

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Main Authors: Acharya, Priyamvada, Luongo, Timothy, Louder, Mark K., McKee, Krisha, Yang, Yongping, Kwon, Young Do, Mascola, John R., Kessler, Pascal, Martin, Loïc, Kwong, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140785/
https://ncbi.nlm.nih.gov/pubmed/23707685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.04.015
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