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HIV-1 gp120 as a therapeutic target: Navigating a moving labyrinth

INTRODUCTION: The HIV-1 gp120 envelope (Env) glycoprotein mediates attachment of virus to human target cells that display requisite receptors, CD4 and co-receptor, generally CCR5. Despite high affinity interactions with host receptors and proof-of-principle by the drug maraviroc that interference wi...

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Pubblicato in:Expert Opin Ther Targets
Autori principali: Acharya, Priyamvada, Lusvarghi, Sabrina, Bewley, Carole A., Kwong, Peter D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711772/
https://ncbi.nlm.nih.gov/pubmed/25724219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.2015.1010513
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