Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to anal...

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Detalhes bibliográficos
Main Authors: Huang, Chih-chin, Lam, Son N., Acharya, Priyamvada, Tang, Min, Xiang, Shi-Hua, Hussan, Syed Shahzad-ul, Stanfield, Robyn L., Robinson, James, Sodroski, Joseph, Wilson, Ian A., Wyatt, Richard, Bewley, Carole A., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278242/
https://ncbi.nlm.nih.gov/pubmed/17901336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1145373
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